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KMID : 0380020110260060513
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Korean Journal of Biotechnology and Bioengineering
2011 Volume.26 No. 6 p.513 ~ p.516
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Anticariogenic Activities of Lactobacillus sakei K-7 Isolated from Kimchi
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Moon Jin-Seok
Ahn Ji-Eun
Han A-Reum
Heo Jeong-Seon
Eom Hyun-Ju
Shin Chul-Soo
Choi Hye-Sun
Han Nam-Soo
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Abstract
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The occurrence of dental caries is mainly associated with oral pathogens, especially cariogenic Streptococcus mutans. The aim of this study was to isolate and characterize lactic acid bacterium showing inhibitory activity against cariogenic Streptococcus mutans. As results, an isolate with strong inhibitory activity was obtained from Kimchi and it was identified as Lactobacillus sakei by API and 16S rRNA gene analyses. This strain secreted an inhibitory compound in cell growth medium and the activity of the compound was completely disappeared by proteinase K revealing the fact that the compound is proteinous substance, bacteriocin. Optimal culture condition for bacteriocin production by Lb. sakei K-7 was at pH 7.5 and 37oC for 18 h. Oral administration of this isolate may give anticariogenic and probiotic effects on hosts.
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KEYWORD
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Dental caries, Kimchi, Lactobacillus sakei, Bacteriocin
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